Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 30420754.
- Also identified by DOI 10.1038/s41591-018-0238-9 and PMC identifier 6322556.
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Abstract
We report the first case series of immune checkpoint inhibitors (ICI)-associated colitis successfully treated with fecal microbiota transplantation, with reconstitution of the gut microbiome and a relative increase in the proportion of regulatory T-cells within the colonic mucosa. These preliminary data provide evidence that modulation of the gut microbiome may abrogate ICI-associated colitis.
Medical subject headings
- Colitis
- Fecal Microbiota Transplantation
- Gastrointestinal Microbiome
- Ipilimumab