RNA Therapeutics for Tissue Engineering.
Level V
Where this comes from
- Record sourced from PubMed, PMID 30426843.
- Also identified by DOI 10.1089/ten.TEA.2018.0315.
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Abstract
RNA has several theoretical advantages as a therapeutic agent, but exploiting RNA in this fashion has faced several major hurdles. Not only is it unstable and difficult to deliver across hydrophobic cell membranes, but extraneous RNA also activates innate immune nucleic acid sensors, which makes it toxic and inflammatory.
Medical subject headings
- Cell Membrane
- Immunity, Innate
- RNA
- Tissue Engineering