Non-mendelian Inheritance in Mammals Is Highly Constrained.

Isbel, Luke; Schübeler, Dirk · Cell · 2018

basic_science · Level V

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Abstract

In this issue, Kazachenka, Bertozzi, and colleagues identify elements in the mouse genome with epigenetic variability between littermates, a phenomenon linked to transmission of phenotypes over generations. This addresses two questions that remained unanswered despite intense speculation: how prevalent are these alleles, and what is their effect, within and across generations?

Medical subject headings