Automated sequential chromogenic IHC double staining with two HRP substrates.

Petersen, Kenneth Heesche; Lohse, Jesper; Ramsgaard, Lasse · PLoS One · 2018

basic_science · Level V

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Abstract

Automated IHC double staining using diaminobenzidine and HRP Magenta is illustrated utilizing a new acidic block with sulfuric acid to prevent cross-reactivity. Residual cross-reactivity in double staining is determined to arise from chromogenic-bound antibodies and amplification system during the first part of the double staining.

Medical subject headings