The Microbiome Modeling Toolbox: from microbial interactions to personalized microbial communities.

Baldini, Federico; Heinken, Almut; Heirendt, Laurent; Magnusdottir, Stefania; Fleming, Ronan M T; Thiele, Ines · Bioinformatics · 2019

basic_science · Level V

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Abstract

The application of constraint-based modeling to functionally analyze metagenomic data has been limited so far, partially due to the absence of suitable toolboxes. To address this gap, we created a comprehensive toolbox to model (i) microbe-microbe and host-microbe metabolic interactions, and (ii) microbial communities using microbial genome-scale metabolic reconstructions and metagenomic data. The Microbiome Modeling Toolbox extends the functionality of the constraint-based reconstruction and analysis toolbox. The Microbiome Modeling Toolbox and the tutorials at https://git.io/microbiomeModelingToolbox.

Medical subject headings