pH-Induced reorientation of cytochrome c on silica nanoparticles.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30468443.
- Also identified by DOI 10.1039/c8sm01909f.
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Abstract
The orientation of cytochrome c molecules at the surface of silica nanoparticles was studied in a wide pH range by combining small-angle neutron scattering, adsorption measurements, and molecular dynamics simulations. The results indicate a reorientation of the ellipsoidal protein from head-on to side-on as the pH is increased. This is attributed to changes in the surface charge distribution of both the protein and the nanoparticles.
Medical subject headings
- Cytochromes c
- Nanoparticles
- Silicon Dioxide