Endocytosis at the <i>Drosophila</i> blood-brain barrier as a function for sleep.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30475209.
- Also identified by DOI 10.7554/eLife.43326 and PMC identifier 6255390.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Glia are important modulators of neural activity, yet few studies link glia to sleep regulation. We find that blocking activity of the endocytosis protein, dynamin, in adult <i>Drosophila</i> glia increases sleep and enhances sleep need, manifest as resistance to sleep deprivation. Surface glia comprising the fly equivalent of the blood-brain barrier (BBB) mediate the effect of dynamin on sleep. Blocking dynamin in the surface glia causes ultrastructural changes, albeit without compromising the integrity of the barrier. Supporting a role for endocytic trafficking in sleep, a screen of Rab GTPases identifies sleep-modulating effects of the recycling endosome Rab11 in surface glia. We also find that endocytosis is increased in BBB glia during sleep and reflects sleep need. We propose that endocytic trafficking through the BBB represents a function of sleep.
Medical subject headings
- Drosophila
- Endocytosis
- Neuroglia
- Sleep