Densely-Connected Multi-Magnification Hashing for Histopathological Image Retrieval.

Abstract

Content-based medical image retrieval is an important computer-aided diagnosis technique providing the clinicians with interpretative references based on visual similarity. In this paper, we focus on the tasks of histopathological image retrieval for breast cancer diagnosis. The densely-connected multi-magnification (DCMMH) framework is proposed to generate the discriminative binary codes by exploiting the histopathological images with multiple magnification factors. The low-magnification images are boosted by the accumulated similarity based on local patches that also regularize the feature learning of high-magnification images. In order to fully utilize the information across different magnification levels, a densely-connected architecture is finally deployed for high-low magnification pairs of datasets. Experiments on BreakHis dataset demonstrate that, DCMMH outperforms the previous hashing methods on histopathological image retrieval.