Pd(OAc)<sub>2</sub>-catalyzed asymmetric hydrogenation of sterically hindered N-tosylimines.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30479338.
- Also identified by DOI 10.1038/s41467-018-07462-w and PMC identifier 6258694.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Asymmetric hydrogenation of sterically hindered substrates still constitutes a long-standing challenge in the area of asymmetric catalysis. Herein, an efficient palladium acetate (an inexpensive Pd salt with low toxicity) catalyzed asymmetric hydrogenation of sterically hindered N-tosylimines is realized with high catalytic activities (S/C up to 5000) and excellent enantioselectivities (ee up to 99.9%). Quantum chemical calculations suggest that uniformly high enantioselectivities are observed due to the structurally different S- and R-reaction pathways.