<i>SOX</i>-<i>6</i>, <i>9</i>-Transfected Adipose Stem Cells to Treat Surgically-Induced Osteoarthritis in Goats.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30484378.
- Also identified by DOI 10.1089/ten.TEA.2018.0189.
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Abstract
We developed <i>SOX</i>-<i>6</i>, <i>9</i>-transfected human adipose stem cells (<sup><i>SOX</i>-<i>6</i>, <i>9</i></sup>ASCs) to treat osteoarthritis (OA). <i>SOX</i>-<i>6</i>, <i>9</i>-transfection led to <i>in vitro</i> chondrogenesis of adipose stem cells (ASCs) comparable to that achieved by growth factor treatment. Intra-articular injection of <i>SOX</i>-<i>6</i>, <i>9</i>-transfected ASCs reduced the progression of surgically-induced OA in goats. <i>In vivo</i> tracking of transfected cell suggested paracrine mode of action. We think that <i>SOX</i>-<i>6</i>, <i>9</i>-transfected ASC provides a novel potential strategy for the treatment of OA.
Medical subject headings
- Adipose Tissue
- Osteoarthritis
- SOX9 Transcription Factor
- SOXD Transcription Factors
- Stem Cells
- Transfection