Depression and antidepressant medications: both are linked to increased fracture risk.

Abstract

Our series of meta-analyses showed that depression and antidepressant use are linked independently to an increased risk of fracture. However, in our meta-analysis research we never dismiss the possible of additional contributions of antidepressants to fractures, nor underestimate the role antidepressants play in the risk of fractures. Existing data indicates that the underlying mechanisms of the impact of depression and antidepressant on fracture risk are likely to be different. We agreed with Dr. Donzelli and his colleagues that promotion of physical activity and exercise, as well as effective psychotherapeutic intervention, is important to prevent and treat mild depression. However, determining if pharmacological therapies are needed, and which medication(s) should be prescribed for individual patients, should be done in clinic, on a case-by-case basis. Different adverse effects, varied impact on risk of fracture by antidepressant medication, severity of depression, and effectiveness of non-medication treatments should all be considered in clinical situations, in order to determine if pharmacological therapies are needed and how to treat individual patients.