Examining the current standards for genetic discovery and replication in the era of mega-biobanks.
Level V
Where this comes from
- Record sourced from PubMed, PMID 30498205.
- Also identified by DOI 10.1038/s41467-018-07348-x and PMC identifier 6265242.
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Abstract
With the recent deluge of mega-biobank data, it is time to revisit what constitutes "replication" for genome-wide association studies. Many replication samples are unavailable or underpowered, therefore alternatives beyond strict statistical replication are needed until the required resources become available.
Medical subject headings
- Genome-Wide Association Study