Mechanobiology of Protein Droplets: Force Arises from Disorder.
editorial · Level V
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- Record sourced from PubMed, PMID 30500530.
- Also identified by DOI 10.1016/j.cell.2018.11.020.
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Abstract
The use of optogenetic approaches has revealed new roles for intracellular protein condensates described in two papers in this issue of Cell (Bracha et. al., 2018; Shin et al., 2018). These results show that growing condensates are able to exert mechanical forces resulting in chromatin rearrangement, establishing a new role for liquid-liquid phase separation in the mechanobiology of the cell.
Medical subject headings
- Proteins