Comparing phenotypic variation between inbred and outbred mice.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 30504873.
- Also identified by DOI 10.1038/s41592-018-0224-7 and PMC identifier 6518396.
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Abstract
Inbred mice are preferred over outbred mice with the assumption that they display less trait variability. We compared coefficients of variation and failed to find evidence of greater trait stability in inbred mice. We conclude that contrary to conventional wisdom, outbred mice may be better subjects for most biomedical research.
Medical subject headings
- Biological Variation, Population
- Genetic Variation