Cancer-Induced Endoplasmic Reticulum Stress in T Cells Subverts Immunosurveillance.
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- Record sourced from PubMed, PMID 30517892.
- Also identified by DOI 10.1016/j.cmet.2018.11.003.
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Abstract
Compelling evidence indicates that tumors may evade immunosurveillance by subverting the metabolism of immune cells. In a recent paper in Nature, Song et al. (2018) demonstrate that ovarian cancers activate IRE1α-XBP1 signaling within CD4+ T lymphocytes, thereby disrupting their bioenergetic function and contribution to anticancer immune responses.
Medical subject headings
- Endoribonucleases
- Ovarian Neoplasms