HER2 Signaling Hijacks the Creatine Shuttle to Fuel Breast Cancer Cell Growth.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30517893.
- Also identified by DOI 10.1016/j.cmet.2018.11.009.
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Abstract
Alteration of cell energy metabolism represents a major determinant of cancer progression; however, our understanding of oncogenic mechanisms underlying this rewiring remains elusive. In this issue of Cell Metabolism, Kurmi et al. (2018) show that HER2 signaling promotes ABL-mediated phosphorylation of the mitochondrial creatine kinase (MtCK1), providing ATP to support breast tumor growth.
Medical subject headings
- Breast Neoplasms
- Erb-b2 Receptor Tyrosine Kinases