The emerging link between cancer, metabolism, and circadian rhythms.
review · Level V
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- Record sourced from PubMed, PMID 30523327.
- Also identified by DOI 10.1038/s41591-018-0271-8 and PMC identifier 6535395.
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Abstract
The circadian clock is a complex cellular mechanism that, through the control of diverse metabolic and gene expression pathways, governs a large array of cyclic physiological processes. Epidemiological and clinical data reveal a connection between the disruption of circadian rhythms and cancer that is supported by recent preclinical data. In addition, results from animal models and molecular studies underscore emerging links between cancer metabolism and the circadian clock. This has implications for therapeutic approaches, and we discuss the possible design of chronopharmacological strategies.
Medical subject headings
- Circadian Rhythm
- Metabolism
- Neoplasms