Interleukin-37 Protects Stem Cell-Based Cartilage Formation in an Inflammatory Osteoarthritis-Like Microenvironment.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30526407.
- Also identified by DOI 10.1089/ten.TEA.2018.0267.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Catabolic factors present in a damaged joint inhibit chondrogenic differentiation of mesenchymal stem cells, thereby reducing the chance for successful cartilage formation. By improving stem cell-based cartilage repair with interleukin-37 (IL37), we might be able to inhibit the worsening progression of focal cartilage defects and prevent further development of joint diseases such as osteoarthritis. This will avoid chronic pain and impaired joint mobility for patients and reduce costs for society.
Medical subject headings
- Cellular Microenvironment
- Chondrogenesis
- Cytoprotection
- Inflammation
- Interleukin-1
- Mesenchymal Stem Cells
- Osteoarthritis