Getting Past HSC Security: Cyclosporine H Gives Lentiviruses an Entry Pass.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 30526877.
- Also identified by DOI 10.1016/j.stem.2018.11.008.
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Abstract
In this issue of Cell Stem Cell, Petrillo et al. (2018) improve lentiviral transduction of hematopoietic stem cells (HSCs) by using cyclosporine H to relieve viral entry restriction by interferon-induced transmembrane protein 3 (IFITM3). This finding promises to enhance the efficiency of ex vivo therapeutic gene transfer and gene editing of HSCs.
Medical subject headings
- Gene Editing
- Lentivirus