The efficacy and safety of pharmacologic thromboprophylaxis following caesarean section: A systematic review and meta-analysis.
meta_analysis · Level I
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- Record sourced from PubMed, PMID 30532233.
- Also identified by DOI 10.1371/journal.pone.0208725 and PMC identifier 6287903.
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Abstract
Our purpose is to evaluate the efficacy and safety of pharmacologic thromboprophylaxis following caesarean section (CS). We searched PubMed, Embase, and the Cochrane Library. Then the systematic review was performed by analysing studies that met the eligibility criteria. Seven studies with 1243 participants were included, including 6 RCTs and 1 prospective cohort. Results from the meta-analysis showed that low molecular weight heparin (LMWH) was associated with no obvious decrease in the risk of thrombus compared with UHF and negative control. However, LMWH was observed to be associated with a definite increase in the risk of bleeding or haematomas in comparison to negative control (RR: 8.47, CI: 1.52-47.11). According to current evidences, the efficacy of pharmacologic thromboprophylaxis which increases the risk of bleeding or hematomas remains controversial.
Medical subject headings
- Cesarean Section
- Fibrinolytic Agents
- Postoperative Complications
- Venous Thrombosis