Phase Separation, Protein Disorder, and Enhancer Function.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30550782.
- Also identified by DOI 10.1016/j.cell.2018.11.034.
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Abstract
New findings suggest that transcription enhancers work by recruitment of a large dynamic network of coactivators and other factors responsible for gene activation. Formation of these condensates is driven by DNA-bound transcription factors, their intrinsically disordered activation domains, and dynamic low-specificity interactions within the complex.
Medical subject headings
- DNA
- Transcription Factors