N<sup>4</sup>-acetylation of Cytidine in mRNA by NAT10 Regulates Stability and Translation.
basic_science · Level V
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- Record sourced from PubMed, PMID 30550783.
- Also identified by DOI 10.1016/j.cell.2018.11.037.
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Abstract
Arango et al. expand the repertoire of epitranscriptomic modifications by identifying N<sup>4</sup>-acetylcytidine in mRNA catalyzed by the known dual acetyltransferase NAT10. It occurs mainly in the coding sequence, likely in wobble positions of select codons, where it promotes stability and translation, possibly by safeguarding cognate codon-anticodon interaction.
Medical subject headings
- Anticodon
- Cytidine