Deception through Mimicry: A Cellular Antiviral Strategy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30550784.
- Also identified by DOI 10.1016/j.cell.2018.11.033.
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Abstract
Viruses use mimicry to hijack cellular machinery, but can human cells use mimicry as an antiviral approach? Batra et al. identify a novel antiviral restriction factor, RBBP6, by characterizing the cellular interactome of Ebola virus. RBBP6 targets the Ebola virus transcription factor VP30 by mimicking the binding of Ebola virus nucleoprotein.
Medical subject headings
- Antiviral Agents
- Ebolavirus
- Hemorrhagic Fever, Ebola