Female XX sex chromosomes increase survival and extend lifespan in aging mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30560587.
- Also identified by DOI 10.1111/acel.12871 and PMC identifier 6351820.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Female longevity is observed in humans and much of the animal kingdom, but its causes remain elusive. Using a genetic manipulation that generates XX and XY mice, each with either ovaries or testes, we show that the female XX sex chromosome complement increases survival during aging in male and female mice. In combination with ovaries, it also extends lifespan. Understanding causes of sex-based differences in aging could lead to new pathways to counter age-induced decline in both sexes.
Medical subject headings
- Longevity
- X Chromosome