Impaired Transplacental Transfer of Respiratory Syncytial Virus-neutralizing Antibodies in Human Immunodeficiency Virus-infected Versus -uninfected Pregnant Women.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 30561563.
- Also identified by DOI 10.1093/cid/ciy1071.
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Abstract
Human immunodeficiency virus (HIV)-exposed, uninfected infants have higher risks of respiratory syncytial virus-associated hospitalization than HIV-unexposed infants. Despite similar neutralizing antibody titers between HIV-infected and -uninfected women, maternal HIV infection and hypergammaglobulinemia were independently associated with lower titers in newborns. Maternal hypergammaglobulinemia was associated with lower cord-to-maternal antibody ratio.
Medical subject headings
- Antibodies, Neutralizing
- Antibodies, Viral
- HIV Infections
- Immunity, Maternally-Acquired
- Respiratory Syncytial Virus, Human