Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial.

Porco, Travis C; Hart, John; Arzika, Ahmed M; Weaver, Jerusha; Kalua, Khumbo; Mrango, Zakayo; Cotter, Sun Y; Stoller, Nicole E et al. · Clin Infect Dis · 2019

rct · Level I

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Abstract

In a large community-randomized trial, biannual azithromycin distributions significantly reduced postneonatal childhood mortality in sub-Saharan African sites. Here, we present a prespecified secondary analysis showing that much of the protective effect was in the first 3 months postdistribution. Distributing more frequently than biannually could be considered if logistically feasible. Clinical Trials Registration. NCT02047981.

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