Treatment-resistant depression: problematic illness or a problem in our approach?

Malhi, Gin S; Das, Pritha; Mannie, Zola; Irwin, Lauren · Br J Psychiatry · 2019

editorial · Level V

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Abstract

Treatment-resistant depression is widely defined as non-response to two 'adequate' courses of treatment. However, the definitions of treatment and depression are inconsistent reflecting gaps in our understanding. We argue that a failure to respond is often the result of administering inappropriate treatment, which occurs principally because of paradigm failure.Declaration of interestNone.

Medical subject headings