Beta<sub>1</sub>-Adrenergic Receptor Regulation Revisited.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 30571467.
- Also identified by DOI 10.1161/CIRCRESAHA.118.313884 and PMC identifier 6333418.
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Abstract
The actions and regulation of cardiomyocyte β<sub>1</sub>ARs differ in several respects from the properties described for the prototypical β<sub>2</sub>AR subtype; a mechanism to explain the unique properties of the β<sub>1</sub>AR subtype has never been obvious. This viewpoint summarizes recent studies that identify a novel signaling paradigm for the β<sub>1</sub>AR, implicating the N-terminus as a molecular determinant of β<sub>1</sub>AR responsiveness.
Medical subject headings
- Heart Diseases
- Myocytes, Cardiac
- Receptors, Adrenergic, beta