Multiple Brain Metastases from Pancreatic Adenocarcinoma Manifesting with Simultaneous Intratumoral Hemorrhages.

Abstract

Pancreatic adenocarcinoma rarely metastasizes to the brain, and clinical features of brain metastasis in such cases remain elusive. To the best of our knowledge, only 21 cases of brain metastasis from pancreatic adenocarcinoma have been previously reported in the English language literature. A 61-year-old woman was diagnosed with pancreatic adenocarcinoma and began chemotherapy 1 year 4 months before the current admission. Three days before the current admission, she developed acute dysarthria. She was referred to a cancer center, where neuroradiologic examination showed multiple metastatic brain tumors, including a 30-mm-diameter tumor in the right cerebellar region. She was transferred to our institute. Three days after admission, she developed sudden-onset disturbance of consciousness and left hemiparesis. Computed tomography and magnetic resonance imaging of the head showed that the metastatic lesions had increased in size with development of intratumoral hemorrhage and obstructive hydrocephalus. She underwent urgent removal of the tumor in the cerebellum. Obstructive hydrocephalus was relieved, and her consciousness improved immediately after surgery. She was transferred to the palliative care unit of the cancer center and died under hospice care 3 weeks after surgery. This case demonstrates that brain metastases from pancreatic adenocarcinoma can enlarge suddenly and simultaneously with intratumoral hemorrhage even without coagulation disorders, resulting in neurologic deterioration in a short time. Surgical resection of metastatic brain lesions from pancreatic adenocarcinoma has an extremely limited role, but such treatment can remove neurologic symptoms and temporarily improve the patient's quality of life in selected cases.