Changes in incidence and prevalence of human papillomavirus in tonsillar and base of tongue cancer during 2000-2016 in the Stockholm region and Sweden.
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- Record sourced from PubMed, PMID 30584688.
- Also identified by DOI 10.1002/hed.25585.
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Abstract
Tonsillar and base of tongue squamous cell carcinoma (TSCC/BOTSCC) has increased. In Stockholm, the proportion of human papillomavirus (HPV)-positive cases and the incidence of TSCC rose between 1970 and 2006 then stabilized. Here, HPV-prevalence, and TSCC/BOTSCC incidence 2000-2016, in Stockholm and Sweden were followed. Incidence data for 2000-2016 were obtained from the Swedish Cancer Registry. TSCC/BOTSCC biopsies, 2013-2016 from Stockholm, were examined for HPV DNA and p16<sup>INK4a</sup> , or data obtained from medical reports. For cases 2000-2012, data were available from previous studies. The incidence of TSCC/BOTSCC has continued to rise in Stockholm and Sweden 2000-2016, especially after 2008. HPV DNA and p16<sup>INK4a</sup> analysis was determined for 795 Stockholm cases from 2000 to 2016, with 72% being HPV DNA and p16<sup>INK4a</sup> positive 2013-2016, and 70% positive 2000-2016. During 2000-2016, especially after 2008, the incidence of TSCC/BOTSCC has continued to increase in Stockholm and Sweden, with an HPV-prevalence of approximately 70% in Stockholm.
Medical subject headings
- Carcinoma, Squamous Cell
- Papillomavirus Infections
- Tongue Neoplasms
- Tonsillar Neoplasms