Limited detection of human polyomaviruses in Fanconi anemia related squamous cell carcinoma.
Where this comes from
- Record sourced from PubMed, PMID 30589865.
- Also identified by DOI 10.1371/journal.pone.0209235 and PMC identifier 6307729.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Fanconi anemia is a rare genome instability disorder with extreme susceptibility to squamous cell carcinoma of the head and neck and anogenital tract. In patients with this inherited disorder, the risk of head and neck cancer is 800-fold higher than in the general population, a finding which might suggest a viral etiology. Here, we analyzed the possible contribution of human polyomaviruses to FA-associated head and neck squamous cell carcinoma (HNSCC) by a pan-polyomavirus immunohistochemistry test which detects the T antigens of all known human polyomaviruses. We observed weak reactivity in 17% of the HNSCC samples suggesting that based on classical criteria, human polyomaviruses are not causally related to squamous cell carcinomas analyzed in this study.
Medical subject headings
- Fanconi Anemia
- Polyomavirus
- Squamous Cell Carcinoma of Head and Neck