Discovery of Half-life of Circulating Hepatitis B Surface Antigen in Patients With Chronic Hepatitis B Infection Using Heavy Water Labeling.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 30590481.
- Also identified by DOI 10.1093/cid/ciy1100.
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Abstract
In a pilot study, heavy water labeling was used to determine hepatitis B surface antigen (HBsAg) turnover rates in chronic hepatitis B (CHB) patients. The mean (standard deviation) half-life of HBsAg in blood was 6.7 (5.5) days, which reflects recent production in the liver and supports strategies aimed at reducing HBsAg production in CHB patients.
Medical subject headings
- Deuterium Oxide
- Hepatitis B Surface Antigens
- Hepatitis B, Chronic