Altered Expression of PYCARD, Interleukin 1β, Interleukin 18, and NAIP in Successfully Treated HIV-Positive Patients With a Low Ratio of CD4+ to CD8+ T Cells.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 30590710.
- Also identified by DOI 10.1093/infdis/jiy730.
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Abstract
The expression and activity of main inflammasome components in monocytes from successfully treated human immunodeficiency virus (HIV)-positive patients are poorly studied. Thus, we enrolled 18 patients with a low and 17 with a normal ratio of CD4+ T cells to CD8+ T cells and 11 healthy donors. We found that patients with a low ratio had decreased CCR2 expression among classical and intermediate monocytes and increased CCR5 expression among classical monocytes, compared with patients with a normal ratio. Patients with a low ratio also had higher NAIP and PYCARD messenger RNA levels after lipopolysaccharide stimulation, suggesting an altered ability to control immune activation that could affect their immune reconstitution.
Medical subject headings
- CARD Signaling Adaptor Proteins
- HIV Infections
- Inflammasomes
- Interleukin-18
- Interleukin-1beta
- Neuronal Apoptosis-Inhibitory Protein