The SMILES trial: do undisclosed recruitment practices explain the remarkably large effect?
Level V
Where this comes from
- Record sourced from PubMed, PMID 30591065.
- Also identified by DOI 10.1186/s12916-018-1221-5 and PMC identifier 6309075.
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Abstract
The SMILES trial showed substantial improvement of depressive symptoms following seven consultations on healthy dieting. The very large effect size on depression reduction seems remarkable and we suggest that selectively induced expectancy and a loss of blinding have contributed to the observed effect.
Medical subject headings
- Depression
- Major Depressive Disorder