Obstructive sleep apnea treatment, slow wave activity, and amyloid-β.
other
Where this comes from
- Record sourced from PubMed, PMID 30597615.
- Also identified by DOI 10.1002/ana.25408 and PMC identifier 6396979.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Obstructive sleep apnea (OSA) increases risk of dementia, a relationship that may be mediated by amyloid-β (Aβ) and downstream Alzheimer disease pathology. We previously showed that OSA may impair Aβ clearance and affect the relationship between slow wave activity (SWA) and Aβ. In this study, SWA and CSF Aβ were measured in participants with OSA before and 1 to 4 months after treatment. OSA treatment increased SWA, and SWA was significantly correlated with lower Aβ after treatment. Greater improvement in OSA was associated with greater decreases in Aβ. We propose a model whereby OSA treatment may affect both Aβ release and clearance. Ann Neurol 2018 ANN NEUROL 2019;85:291-295.
Medical subject headings
- Continuous Positive Airway Pressure
- Sleep Apnea, Obstructive
- Sleep, Slow-Wave