Pemphigus vulgaris - A report of three cases and review of literature.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 30598970.
- Also identified by DOI 10.4103/jfmpc.jfmpc_133_18 and PMC identifier 6259552.
- Licence recorded as CC BY-NC-SA.
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Abstract
Pemphigus vulgaris (PV) is an autoimmune, potentially life-threatening disease causing blisters and erosions of the skin and mucous membranes associated with intraepithelial acantholysis. The underlying mechanism responsible for causing intraepithelial lesions is the binding of immunoglobulin G autoantibodies to desmoglein 3, a transmembrane glycoprotein adhesion molecule present on desmosomes. Histological features comprise intraepithelial cleft and Tzanck cells. Corticosteroids remain the mainstay of the treatment plan. In this article, we have discussed about the diagnosis of three patients suffering from PV, the treatment rendered, and the outcome of the same.