Type I Protein Arginine Methyltransferases Overexpression Promotes Transformation and Potentiates Her2/Neu-Driven Tumorigenesis.
editorial · Level V
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- Record sourced from PubMed, PMID 30602621.
- Also identified by DOI 10.1158/0008-5472.CAN-18-3552.
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Abstract
Bao and colleagues demonstrate that type I protein arginine methyltransferases (PRMT) are directly involved in mammary gland transformation and tumor progression. Notably, several distinct phenotypes require further investigation such as PRMT1/CARM1-induced transformation, CARM1-mediated delay in tumorigenesis, and PRMTs potentiation of Her2-dependent tumors. The PRMT overexpression transgenic mouse models should encourage and facilitate further mechanistic interrogation and the development of PRMT-directed therapies.<i>See related article by Bao et al., p. 21</i>.
Medical subject headings
- Neoplasms
- Protein-Arginine N-Methyltransferases