Huntington Disease's Glial Progenitor Cells Hit the Pause Button in the Mouse Brain.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 30609397.
- Also identified by DOI 10.1016/j.stem.2018.12.004.
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Abstract
White matter abnormalities are prominent neuropathological features in Huntington's disease (HD); however, the cellular culprits are unclear. In this issue of Cell Stem Cell, Osipovitch et al. (2019) show that patient-derived glial progenitor cells fail to properly differentiate and myelinate in the mouse brain due to cell-intrinsic transcriptional defects.
Medical subject headings
- Huntington Disease