The Making of a Leukemic Stem Cell: A Novel Role for IKZF2 in AML Stemness and Differentiation.
editorial · Level V
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- Record sourced from PubMed, PMID 30609399.
- Also identified by DOI 10.1016/j.stem.2018.12.007.
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Abstract
Identification of key stemness regulators is critical for developing more effective therapies against acute myeloid leukemia stem cells (LSCs). In this issue of Cell Stem Cell, Park et al. (2019) report that IKZF2, a member of the Ikaros family of transcription factors, drives self-renewal and suppresses differentiation in LSCs through modulation of chromatin accessibility.
Medical subject headings
- Cell Self Renewal
- Leukemia, Myeloid, Acute