Insights into atopic dermatitis gained from genetically defined mouse models.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 30612664.
- Also identified by DOI 10.1016/j.jaci.2018.11.014.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Atopic dermatitis (AD) is characterized by severe pruritus and recurrent eczema with a chronic disease course. Impaired skin barrier function, hyperactivated T<sub>H</sub>2 cell-type inflammation, and pruritus-induced scratching contribute to the disease pathogenesis of AD. Skin microbial alterations complicate the pathogenesis of AD further. Mouse models are a powerful tool to analyze such intricate pathophysiology of AD, with a caution that anatomy and immunology of the skin differ between human subjects and mice. Here we review recent understanding of AD etiology obtained using mouse models, which address the epidermal barrier, skin microbiome, T<sub>H</sub>2 immune response, and pruritus.
Medical subject headings
- Dermatitis, Atopic
- Skin
- Th2 Cells