Monoclonal gammopathy of undetermined significance: A primary care guide.

Khouri, Jack; Samaras, Christy; Valent, Jason; Mejia Garcia, Alex; Faiman, Beth; Mathur, Saveta; Hamilton, Kimberly; Nakashima, Megan et al. · Cleve Clin J Med · 2019

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Abstract

Monoclonal gammopathy of undetermined significance (MGUS) is commonly diagnosed in outpatients being worked up for an array of clinical concerns. It carries a risk of progression to myeloma and other lymphoproliferative disorders that, albeit low (1% per year), warrants regular follow-up. Patients with MGUS can be risk-stratified on the basis of the amount and type of their monoclonal protein as well as whether they have an abnormal light-chain ratio. Here, we provide a guide to the diagnosis, workup, and management of MGUS.

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