β Cell Dysfunction in Type 2 Diabetes: Drained of Energy?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 30625305.
- Also identified by DOI 10.1016/j.cmet.2018.12.015.
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Abstract
Type 2 diabetes is a progressive disorder, but exactly how the progression occurs remains unknown. In this issue of Cell Metabolism, Zhang et al. (2019) present evidence that diabetes, via hyperglycemia, leads to aberrant insertion of a mitochondrial ion channel in the plasma membrane, rendering it leaky to key intracellular signaling molecules with resultant suppression of insulin secretion.
Medical subject headings
- Diabetes Mellitus, Type 2
- Hyperglycemia
- Insulin-Secreting Cells