NASH and HCC Are Driven by Different Signaling Pathways with a Common Regulator.
Level V
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- Record sourced from PubMed, PMID 30625307.
- Also identified by DOI 10.1016/j.cmet.2018.12.012.
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Abstract
Oxidative stress is uniformly present in non-alcoholic steatohepatitis (NASH), but its role in the development of liver inflammation and hepatocellular cancer (HCC) and the relationship between these two pathologies are poorly understood. In a recent issue of Cell, Grohmann et al. (2018) demonstrate a vital role of obesity-induced oxidative stress in deactivating the phosphatase TCPTP, resulting in activation of STAT-1 and STAT-3, which each independently drive the development of NASH and HCC, respectively.
Medical subject headings
- Carcinoma, Hepatocellular
- Liver Neoplasms
- Non-alcoholic Fatty Liver Disease