Complement C3 and Autophagy Keep the β Cell Alive.
Where this comes from
- Record sourced from PubMed, PMID 30625308.
- Also identified by DOI 10.1016/j.cmet.2018.12.010.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Autophagy prevents pancreatic β cell death during obesity, although the mechanism of autophagy activation in the β cell has remained elusive. In this issue of Cell Metabolism, King et al. (2018) show that intracellular complement component C3 interacts with autophagy protein ATG16L1 and protects against β cell death by stimulating autophagy.
Medical subject headings
- Autophagy
- Insulin-Secreting Cells