Moving beyond GWAS and eQTL Analysis to Validated Hits in Chronic Kidney Disease.
editorial · Level V
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- Record sourced from PubMed, PMID 30625310.
- Also identified by DOI 10.1016/j.cmet.2018.12.009.
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Abstract
Genome-wide association studies (GWAS) have identified multiple chronic kidney disease (CKD)-associated single-nucleotide polymorphisms (SNPs) mainly localized to non-coding genomic regions. To understand which genes and which cell types are affected by these genetic variants, compartment-specific transcriptome, genome, and epigenome data were analyzed in an integrative manner in a recent study by Qiu et al. (Qiu et al., 2018).
Medical subject headings
- Genome-Wide Association Study
- Renal Insufficiency, Chronic