Sex differences in [<sup>11</sup>C]ABP688 binding: a positron emission tomography study of mGlu5 receptors.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 30627817.
- Also identified by DOI 10.1007/s00259-018-4252-4 and PMC identifier 6451701.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The purpose of this study was to assess, in a large sample of healthy young adults, sex differences in the binding potential of [<sup>11</sup>C]ABP688, a positron emission tomography (PET) tracer selective for the metabotropic glutamate type 5 (mGlu5) receptor. High resolution [<sup>11</sup>C]ABP688 PET scans were acquired in 74 healthy volunteers (25 male, 49 female, mean age 20 ± 3.0). Mean binding potential (BP<sub>ND</sub> = f<sub>ND</sub> * (B<sub>avail</sub> / K<sub>D</sub>)) values were calculated in the prefrontal cortex, striatum, and limbic regions using the simplified reference tissue model with cerebellar grey matter as the reference region. [<sup>11</sup>C]ABP688 BP<sub>ND</sub> was significantly higher in men compared to women in the prefrontal cortex (p < 0.01), striatum (p < 0.001), and hippocampus (p < 0.05). Whole-brain BP<sub>ND</sub> was 17% higher in men. BP<sub>ND</sub> was not related to menstrual phase in women. Binding availability of mGlu5 receptors as measured by PET [<sup>11</sup>C]ABP688 is higher in healthy men than women. This likely represents a source of variability in [<sup>11</sup>C]ABP688 studies and could have relevance for sex differences in cognitive-behavioral functions and neuropsychiatric disorders.
Medical subject headings
- Carbon Radioisotopes
- Oximes
- Positron-Emission Tomography
- Pyridines
- Receptor, Metabotropic Glutamate 5
- Sex Characteristics