Post-exposure immunotherapy for two ebolaviruses and Marburg virus in nonhuman primates.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30631063.
- Also identified by DOI 10.1038/s41467-018-08040-w and PMC identifier 6328579.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The 2013-2016 Ebola virus (EBOV) disease epidemic demonstrated the grave consequences of filovirus epidemics in the absence of effective therapeutics. Besides EBOV, two additional ebolaviruses, Sudan (SUDV) and Bundibugyo (BDBV) viruses, as well as multiple variants of Marburg virus (MARV), have also caused high fatality epidemics. Current experimental EBOV monoclonal antibodies (mAbs) are ineffective against SUDV, BDBV, or MARV. Here, we report that a cocktail of two broadly neutralizing ebolavirus mAbs, FVM04 and CA45, protects nonhuman primates (NHPs) against EBOV and SUDV infection when delivered four days post infection. This cocktail when supplemented by the anti-MARV mAb MR191 exhibited 100% efficacy in MARV-infected NHPs. These findings provide a solid foundation for clinical development of broadly protective immunotherapeutics for use in future filovirus epidemics.
Medical subject headings
- Antibodies, Monoclonal
- Antibodies, Neutralizing
- Ebolavirus
- Filoviridae Infections
- Marburgvirus
- Primate Diseases