GABA<sub>A</sub>R Modulator for Postpartum Depression.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 30633900.
- Also identified by DOI 10.1016/j.cell.2018.12.016.
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Abstract
During the postpartum period, the brain's inhibitory GABAA receptors may not recover in time following their reduced numbers during pregnancy. This is likely the cause of postpartum depression prevalent in ∼12% of childbearing women. A new therapy for this condition consists of administering a synthetic neurosteroid during the postpartum period to alleviate the mood disorder. To view this Bench to Bedside, open or download the PDF.
Medical subject headings
- Depression, Postpartum
- Pregnanolone
- Receptors, GABA-A
- beta-Cyclodextrins