An Allosteric Switch Primes Sequence-Specific DNA Recognition.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30633906.
- Also identified by DOI 10.1016/j.cell.2018.12.020 and PMC identifier 6532627.
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Abstract
Regulation of protein-DNA binding specificity occurs through myriad mechanisms. Boudet et al. discover yet a new form of specificity through allosteric regulation, an ATP-induced structural switch that mediates specific DNA recognition in an archaeoeukaryotic primase.
Medical subject headings
- DNA Primase
- Nucleotides