A case of mistaken identity: The MAR-1 antibody to mouse FcεRIα cross-reacts with FcγRI and FcγRIV.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 30639345.
- Also identified by DOI 10.1016/j.jaci.2018.11.045 and PMC identifier 6746400.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
This study demonstrates that the MAR-1 antibody to mouse FcepsilonRI unexpectedly binds to two Fcgamma receptors, raising concerns regarding numerous studies that used this antibody to assess the distribution and function of FcepsilonRI+ cells.
Medical subject headings
- Antibodies, Monoclonal
- Antibody Specificity
- Receptors, IgE
- Receptors, IgG